Semantic Breakthrough in Drug Discovery (Record no. 85259)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04364nam a22005895i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-031-79456-8 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240730164045.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220601s2015 sz | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| ISBN | 9783031794568 |
| -- | 978-3-031-79456-8 |
| 082 04 - CLASSIFICATION NUMBER | |
| Call Number | 510 |
| 100 1# - AUTHOR NAME | |
| Author | Chen, Bin. |
| 245 10 - TITLE STATEMENT | |
| Title | Semantic Breakthrough in Drug Discovery |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | CXXXIV, 10 p. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Synthesis Lectures on Data, Semantics, and Knowledge, |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Remark 2 | Introduction -- Data Representation and Integration Using RDF -- Data Representation and Integration Using OWL -- Finding Complex Biological Relationships in PubMed Articles using Bio-LDA -- Integrated Semantic Approach for Systems Chemical Biology Knowledge Discovery -- Semantic Link Association Prediction -- Conclusions -- References -- Authors' Biographies . |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | The current drug development paradigm---sometimes expressed as, ``One disease, one target, one drug''---is under question, as relatively few drugs have reached the market in the last two decades. Meanwhile, the research focus of drug discovery is being placed on the study of drug action on biological systems as a whole, rather than on individual components of such systems. The vast amount of biological information about genes and proteins and their modulation by small molecules is pushing drug discovery to its next critical steps, involving the integration of chemical knowledge with these biological databases. Systematic integration of these heterogeneous datasets and the provision of algorithms to mine the integrated datasets would enable investigation of the complex mechanisms of drug action; however, traditional approaches face challenges in the representation and integration of multi-scale datasets, and in the discovery of underlying knowledge in the integrated datasets. The Semantic Web, envisioned to enable machines to understand and respond to complex human requests and to retrieve relevant, yet distributed, data, has the potential to trigger system-level chemical-biological innovations. Chem2Bio2RDF is presented as an example of utilizing Semantic Web technologies to enable intelligent analyses for drug discovery.Table of Contents: Introduction / Data Representation and Integration Using RDF / Data Representation and Integration Using OWL / Finding Complex Biological Relationships in PubMed Articles using Bio-LDA / Integrated Semantic Approach for Systems Chemical Biology Knowledge Discovery / Semantic Link Association Prediction / Conclusions / References / Authors' Biographies . |
| 700 1# - AUTHOR 2 | |
| Author 2 | Wang, Huijun. |
| 700 1# - AUTHOR 2 | |
| Author 2 | Ding, Ying. |
| 700 1# - AUTHOR 2 | |
| Author 2 | Wild, David. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | https://doi.org/10.1007/978-3-031-79456-8 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | eBooks |
| 264 #1 - | |
| -- | Cham : |
| -- | Springer International Publishing : |
| -- | Imprint: Springer, |
| -- | 2015. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Mathematics. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Internet programming. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Application software. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Computer networks . |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Ontology. |
| 650 14 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Mathematics. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Web Development. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Computer and Information Systems Applications. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Computer Communication Networks. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Ontology. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| -- | 2691-2031 |
| 912 ## - | |
| -- | ZDB-2-SXSC |
No items available.